The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Prior randomized controlled trials (RCTs) offer inconsistent evidence on extended magnesium supplementation's impact on inflammatory markers within metabolic syndrome cases.

Methods

We conducted a systematic search in Web of Science, PubMed, and Scopus, and the present meta-analysis included eight RCTs involving 444 participants. This meta-analysis adhered to PICOTS criteria and specifically evaluated the effect of oral magnesium supplementation compared to placebo on serum inflammatory markers. Only randomized controlled trials with an intervention duration of at least 2 months were included. Data were synthesized using a random-effects model, with results expressed as standardized mean differences (SMD) and 95% confidence intervals (CI). The risk of bias was ass

SUBMITTER: Wang W 

PROVIDER: S-EPMC12617300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature