TIE1 Promotes Primary Tumor Growth by Inhibiting Apoptosis and Activating the AKT-p70S6K Signaling Pathway in Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among all breast cancer types. Its treatment remains a significant challenge due to the lack of clearly defined molecular targets. We previously reported that lung-metastatic cell lines, established via orthotopic transplantation of a TNBC cell line, showed high expression of the TIE1 receptor-tyrosine kinase. In this study, we demonstrated that TIE1 expression correlates with poor prognosis in breast cancer patients and is highly elevated in the Claudin-low subtype, which largely overlaps with TNBC. Notably, TIE1 expression promoted tumorigenicity in a breast cancer cell line. Furthermore, in primary tumors formed by TIE1-expressing cells, we observed TIE1 cleavage, reduced apoptosis, and activation of the AKT-p

SUBMITTER: Azuma K 

PROVIDER: S-EPMC12617338 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature