Impact of SIRPα genotype combinations in recipients and donors on alloimmune response in liver transplantation.

ABSTRACT: The signal regulatory protein alpha (SIRPα)-CD47 axis regulates self-tolerance by delivering inhibitory signals to phagocytic cells and influencing immune responses in transplantation. This study examined the impact of SIRPα polymorphisms on CD47 binding capacity and T cell activation and analyzed the role of SIRPα genotypes in acute rejection following allogeneic liver transplantation. Peripheral blood mononuclear cells from healthy volunteers and data from liver transplant recipients were analyzed. Results showed that V2 SIRPα exhibited significantly higher CD47 binding capacity and enhanced costimulatory activity on CD4⁺ T cell proliferation compared V1 under both CD28^- and CD28⁺ conditions, with further augmentation in the CD28⁺ setting. In t

SUBMITTER: Seidakhmetov A 

PROVIDER: S-EPMC12617414 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature