Movement Disorders and Oculomotor Abnormalities in Whipple's Disease: An Updated Systematic Review.

ABSTRACT:

Introduction

Whipple's disease (WhD) is a rare multisystemic infection caused by Tropheryma whipplei, with central nervous system (CNS) involvement seen in up to 50% of cases. Neurological symptoms may precede systemic features or occur in isolation. Movement disorders (MDs) and oculomotor abnormalities, especially oculomasticatory myorhythmia (OMM) and oculofacioskeletal myorhythmia (OFSM), are of a high diagnostic importance but remain underrecognized. This systematic review aims to update our understanding of MDs in CNS-WhD, building on a 2018 review.

Methods

A systematic search of MEDLINE, EMBASE, and Cochrane Library was performed for English-language human studies published between 01/2017-05/2025. Search terms targeted WhD and MDs. Titles, abstracts and full-te

SUBMITTER: Maslias E 

PROVIDER: S-EPMC12617415 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature