High-Throughput Microfluidic Technologies for Rapidly Screening Pollutant-Induced Cell Health Effects.

ABSTRACT: Air pollution exposure is linked to diseases spanning multiple physiological systems. However, environmental stress is overwhelmingly associated with several lung diseases. Since the chemical composition of air pollutants varies widely across geographical locations, research on how specific components in pollutant mixtures contribute to cellular dysfunction is needed. In this work, we utilized microscopy-based morphological profiling as a tool to assess the cellular susceptibility to pollutants. Through our analysis, we established morphological profiles of formaldehyde-exposed cells that showed dose-dependent shifts in cell shape profiles correlating with overall cell health. As a real-world proof-of-concept validation, we evaluated the differences in particulate matter (PM) composition a

SUBMITTER: Quinones-Diaz BI 

PROVIDER: S-EPMC12617457 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature