Adaptation of hippocampal spatial and contextual representations to task structure.

ABSTRACT: The hippocampus is fundamental for spatial and contextual memory. CA1 pyramidal neurons (CA1PNs) exhibit spatially tuned activity during navigation, but how their context-dependent tuning evolves during learning and upon context change is incompletely understood. We monitored Ca²⁺ activity of dorsal CA1PNs in mice in a virtual go/no-go task series that required both spatial navigation and rule learning based on nonspatial environmental features. Spatial and context-dependent activity of CA1PNs developed sequentially during learning, parallel with behavioral performance. Upon switching to a new task condition involving familiar and novel environments, neuronal activity disorganized rapidly and extensively even in the unchanged environment. In contrast, reward reversal in unchange

SUBMITTER: Nyilas R 

PROVIDER: S-EPMC12617488 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature