3D printed nerve guidance conduit for biologics-free nerve regeneration and vascular integration.

ABSTRACT: There is a clinical need for an effective nerve guidance conduit to treat peripheral nerve injuries. Many studies have explored different materials and active cues to guide neural regeneration, with some success. However, none have demonstrated a comparable or better functional recovery than the clinical standard autograft. Autografts are often insufficient for reconstruction of an injury to long nerves such as the sciatic or brachial plexus. Synthetic nerve guidance conduits (NGCs) have been investigated for these injuries to guide axonal regeneration and lead to functional recovery. We have designed a biologics-free hydrogel-based multi-channel conduit with defined microscale features to guide axonal outgrowth. To investigate extraneural vascular infiltration and its effects on functiona

SUBMITTER: Schimelman J 

PROVIDER: S-EPMC12617550 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature