Early Oxygenation and Mortality in Infants Treated with Inhaled Nitric Oxide (iNO) for Persistent Pulmonary Hypertension of the Newborn (PPHN).

ABSTRACT:

Objective

To evaluate whether oxygenation levels and exposure to hyperoxemia in the first 12 postnatal hours are associated with death in neonates treated with inhaled nitric oxide for persistent pulmonary hypertension of newborn (PPHN).

Study design

This was a retrospective study of neonates ≥35 weeks with PPHN treated with inhaled nitric oxide. The cohort was divided into 4 groups on the basis of maximum Pao₂ within the first 12 hours: hypoxemia (<60 mm Hg), normoxemia (60-99 mm Hg), mild-moderate (100-199 mm Hg), and severe hyperoxemia (≥200 mm Hg). The primary outcome was death before discharge.

Results

In total, 118 neonates were included. Hypoxemia, normoxemia, and mild-to-moderate and severe hyperoxemia were present in 14%, 36%, 32%, and 17% of infan

SUBMITTER: Oren MS 

PROVIDER: S-EPMC12617620 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature