Nicotine pouch pharmacokinetics compared to smoked tobacco: A systematic review and meta-analysis.

ABSTRACT: Nicotine pouches (NP) are novel agents that deliver nicotine through buccal absorption as opposed to combustion. They are proposed as a harm reduction tool compared to smoking tobacco. However, there is limited evidence on their efficacy and safety. This review article summarizes the current evidence regarding NP pharmacokinetics compared to conventional tobacco products. We searched Medline, Embase, CENTRAL and Scopus for studies that assessed pharmacokinetic parameters of nicotine pouches. We identified studies involving tobacco-dependent adults and examined pharmacokinetic parameters such as total exposure, peak concentration, and time to peak. A meta-analysis was conducted using random-effects models to calculate pooled effect sizes. The Cochrane ROB 2.0 tool was used to evaluate the r

SUBMITTER: Heshmati J 

PROVIDER: S-EPMC12617622 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature