Role of long non-coding RNA Lnc9101 and Lnc8475 in regulation of innate immune response to influenza virus infection.

ABSTRACT: Long non-coding RNAs (lncRNAs) are critical regulators of various biological processes, yet their roles in chicken host-virus interactions remain largely unknown. This study investigated the impact of influenza A virus (IAV) H9N2 infection on the expression of two lncRNAs, Lnc9101 and Lnc8475, and the regulatory roles of these lncRNAs in the innate immune response. The results demonstrated that the expression of both lncRNAs were significantly upregulated in H9N2-infected chickens and could be induced by viral genomic RNA, poly (I:C) or LPS. Disruption of Lnc9101 expression in DF-1 cells enhanced the IAV replication, while its overexpression suppressed it. Conversely, Lnc8475 had the opposite effect on the IAV replication compared with Lnc9101. Silencing Lnc8475 expression in DF-1 cells at

SUBMITTER: Lin J 

PROVIDER: S-EPMC12617630 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature