Subclinical vascular risk composites and dementia imaging biomarkers 17-20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT: Cardiovascular disease (CVD) risk factors captured in midlife represent potentially modifiable features of CVD, stroke, dementia, and dementia-related neuropathology and are included in dementia risk scores. Subclinical measures of CVD represent degrees of subclinical vascular aging. We hypothesize that subclinical vascular measures associated with dementia may help identify specific structural and functional aspects underlying vascular contributions to cognitive impairment and dementia over and above conventional dementia risk scores. Utilizing a large (n = 1420), racially, ethnically, and regionally diverse group of older adults free from clinical CVD at baseline from the Multi-Ethnic Study of Atherosclerosis (MESA), we assessed relationships between factor composites repre

SUBMITTER: Rudolph MD 

PROVIDER: S-EPMC12617641 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature