Immunophenotyping and Mutation Analysis of Canine Intestinal T-Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy-Associated T-Cell Lymphoma.

ABSTRACT: Human enteropathy-associated T-cell lymphoma (EATL) is a rare primary aggressive intestinal T-cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)-like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis. In dogs, the histopathological and immunophenotypic features of intestinal large T-cell lymphoma (ILTCL) are similar to EATL; however, its cell of origin remains unclear. We herein performed detailed immunophenotyping, an RNA expression analysis of selected genes, and gene mutation analysis of 54 cases of ILTCL, including 27 with fresh frozen samples available and 21 of intestinal small T-cell lymphoma (ISTCL) in dogs. Canine ILTCL was characterised

SUBMITTER: Kojima K 

PROVIDER: S-EPMC12617692 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature