Association of pylorus preservation with outcomes of pancreaticoduodenectomy across the United States.

ABSTRACT:

Background

Pylorus-preserving pancreaticoduodenectomy (PPPD) was developed to improve postoperative gastrointestinal function while maintaining oncologic adequacy. However, conflicting evidence and concerns persist regarding increased delayed gastric emptying, warranting a national-level investigation.

Methods

This retrospective cohort study analyzed 40,063 adult pancreaticoduodenectomy procedures from the ACS NSQIP database (2014-2023). Patients were stratified into pylorus-preserving and non-pylorus-preserving groups. Multivariable regression models evaluated independent associations between pylorus-preserving status and clinical outcomes including infectious complications, blood transfusions, delayed gastric emptying, and length of stay.

Results

Of 40,063 pancreati

SUBMITTER: Mahrokhi S 

PROVIDER: S-EPMC12617821 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature