Early disruptions in vitamin D receptor signaling induces persistent developmental behavior deficits in zebrafish larvae.

ABSTRACT: A critical function of the nervous system is to rapidly process sensory information and initiate appropriate behavioral responses. Defects in sensory processing and behavior selection are commonly observed in neuro-psychiatric conditions including anxiety, autism (ASD), and schizophrenia. The etiology of sensory processing disorders remains equivocal; however, it is hypothesized that extrinsic environmental factors can play fundamental roles. In this study we examine the importance of vitamin D (1α, 25-dihydroxyvitamin D3) receptor signaling during early life stage development on sensory processing and neurobehavioral health outcomes. While vitamin D has traditionally been associated with mineral ion homeostasis, accumulating evidence suggests non-calcemic roles for vitamin D including ear

SUBMITTER: Barnes M 

PROVIDER: S-EPMC12617856 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature