Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.

ABSTRACT: Actinobacillus pleuropneumoniae is the primary etiological agent of porcine contagious pleuropneumonia, a devastating respiratory disease that causes substantial economic losses to the global swine industry. The emergence of multidrug-resistant strains with enhanced virulence poses increasing challenges to disease control and necessitates comprehensive genomic characterization to inform targeted intervention strategies. This study aimed to characterize the genomic features, antimicrobial resistance profile, and pathogenic potential of a novel A. pleuropneumoniae strain isolated from a severe outbreak in China, with particular focus on identifying unique resistance mechanisms and virulence determinants. We isolated strain APPFJLYC01 from lung and bronchial tissues of pigs during a severe pl

SUBMITTER: Fang Z 

PROVIDER: S-EPMC12617859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature