Genetic correlation analysis between sepsis and hematological traits: Identifying shared genomic regions.

ABSTRACT:

Background

Sepsis, dysregulated cascades of inflammatory response to infection, remains a critical clinical condition, leading to morbidity and mortality. Better understanding of the genetic basis underlying sepsis has the potential to better prevent and treat this potentially life-threatening condition. Recent studies have identified genetic variants for sepsis and accumulated evidence for the relevance of hematological traits. However, genetic correlation analysis, testing the hypothesis of shared genetic underpinning of sepsis and hematological traits, as well as identifying shared specific genetic regions, is lacking.

Method

In this study, we systematically evaluated the extent and statistical significance of global genetic correlation between sepsis and a comprehensive

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12617866 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature