Antioxidant and antidiabetic effects of Angylocalyx oligophyllus leaves aqueous extract in pregnant diabetic rats: Feto-maternal repercussions.

ABSTRACT: Pregestational diabetes mellitus can lead to many adverse outcomes during pregnancy both in the mother and her embryo/fetus. Plant-based products are empirically used as an alternative strategy to reduce these disorders. To investigate the effects of the Angylocalyx oligophyllus leaves aqueous extract on diabetes-induced metabolic, reproductive and fetal developmental disorders in pregnant diabetic rats, the in vitro anti-α-amylase and antioxidant plant effects first were evaluated. Then, adult virgin female rats primarily made diabetic by streptozotocin (35 mg/kg) and normal ones were mated with adult male rats. The pregnant rats were distributed into normal and diabetic control groups receiving distilled water, and diabetic rats groups treated with the plant extract doses (50, 100 and 20

SUBMITTER: Tenezogang Takoukam C 

PROVIDER: S-EPMC12617868 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature