Early risk factors for acute chest syndrome in sickle cell anemia: A pediatric study.

ABSTRACT: Acute chest syndrome (ACS) is a life-threatening complication of sickle cell anemia (SCA). Most often, ACS occurs during the progression of a painful vaso-occlusive crisis (VOC) in vulnerable patients. The present study aimed to identify early risk factors for ACS progression, focusing on patient assessments in a pediatric Emergency Department. In this study (2016-2022) concerning exclusively the SS and Sβ0 sickle cell disease genotypes, severe VOC encounters progressing to ACS were compared to uncomplicated severe VOCs. Medical history, clinical and laboratory data were collected for both groups. Out of 280 severe VOC encounters without initial respiratory symptoms, 40 progressed to life-threatening acute chest syndrome. The forty ACS (age 8.5 ± 4.3 years, 37% females) were compared with

SUBMITTER: Conde M 

PROVIDER: S-EPMC12617906 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature