Management of Severe Hypercalcemia with Continuous Venovenous Hemodialysis and Regional Citrate Anticoagulation: A Case Report.

ABSTRACT:

Introduction

Severe hypercalcemia is a potentially life-threatening condition that often requires urgent medical intervention, especially when refractory to conventional treatments. Continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA) is a therapeutic option, although data on its use in hypercalcemia are limited.

Case presentation

We report the case of a 78-year-old woman who presented with severe hypercalcemia (4.89 mmol/L, corrected for albumin), ECG changes, muscle weakness, and acute kidney injury. She was unresponsive to standard treatments including crystalloids, diuretics, calcitonin, and bisphosphonates. Imaging revealed multiple lytic bone lesions and a mediastinal mass, with biopsy confirming diffuse large B-cell lymphoma. Continu

SUBMITTER: Hendriks RMF 

PROVIDER: S-EPMC12618022 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature