<i>In vitro</i> Antiplasmodial and Molecular Docking Studies of Chemical Constituent Isolated from the Bark of <i>Diospyros lanceifolia</i> (Ebenaceae).

ABSTRACT: The phytochemical investigations of the ethyl acetate bark extract of Diospyros lanceifolia have led to the isolation of eight compounds, namely lupeol (1), betulin (2), β-sitosterol (3), oleic acid (4), α-amyrin acetate (5), glyceryl trilinoleate (6), β-amyrin (7) and shinanolone (8). The structures of all compounds were established using various spectroscopic techniques such as 1D and 2D-NMR, FT-IR and HRESIMS, which were then compared with reported literature for validation. All compounds isolated from this plant were screened for an in vitro study against Plasmodium falciparum FCR3 followed by an in silico molecular docking study with the PfATP6 protein. The in vitro results revealed that five co

SUBMITTER: Bafarawa ID 

PROVIDER: S-EPMC12618094 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature