Integrative Multiomics Analysis Identifies HK2 as a Key Regulator of Metabolic Reprogramming in Hepatic Stellate Cells.

ABSTRACT:

Background

Liver damage caused by chronic liver disease frequently leads to hepatic fibrosis. A pivotal step in the fibrotic process is the activation of hepatic stellate cells (HSCs). Previous studies have suggested that enhanced aerobic glycolysis is closely associated with HSC activation. However, a comprehensive analysis of the relationship between hepatic fibrosis and aerobic glycolysis remains lacking.

Methods

RNA sequencing of liver tissue from 30 patients with fibrosis or cirrhosis and 8 healthy controls was conducted as part of a comprehensive multiomics approach to discover differentially expressed genes (DEGs). Weighted gene coexpression network analysis (WGCNA) was conducted to detect gene modules associated with liver fibrosis. Functional analyses, including mig

SUBMITTER: Han L 

PROVIDER: S-EPMC12618131 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature