Open-label Prospective, Interventional Study Assessing Efficacy and Safety of Intramuscular Ketamine for Suicidal Ideation in a Tertiary Care Hospital.

ABSTRACT:

Background

This study evaluated intramuscular (IM) ketamine's efficacy and safety for rapid suicidal ideation reduction, addressing the critical need for fast-acting interventions in resource-limited settings where intravenous (IV) options are impractical.

Methods

We conducted a pre-post-interventional study of IM ketamine (0.5 mg/kg) over one year after approval of the institutional ethics committee. Adult patients with suicidal ideation, as measured by the six-point Montgomery-Åsberg Depression Rating Scale-Suicidal Ideation (MADRS-SI), were included if their MADRS-SI score was >4. Post-injection monitoring of suicidal ideation and adverse effects (A/E) was done after two hours and on Days 1, 3, 7, 14, 21, and 28. A repeat injection of the same dose was given only if the M

SUBMITTER: Sanspara MM 

PROVIDER: S-EPMC12618211 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature