Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.

ABSTRACT: Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (T_SCM) and naive T cells in mice. In this randomized, double-blind, placebo-controlled trial, 50 healthy middle-aged adults received oral UA (1,000 mg day^-1) or placebo for 4 weeks; time points of analysis were baseline and day 28. Primary outcomes were phenotypical changes in peripheral CD3⁺ T cell subsets and immune metabolic remodeling. UA expanded peripheral naive-like, less terminally exhausted CD8⁺ cells (treatment difference 0.50 percentage points; 95% CI = 0.16 to 0.83; P = 0.0437) while a

SUBMITTER: Denk D 

PROVIDER: S-EPMC12618261 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature