B355252 Targets UCP2 to Rescue Intracerebral Hemorrhage-Induced Injury by Promoting Mitochondrial Fusion and Inhibiting Ferroptosis.

ABSTRACT: Intracerebral hemorrhage (ICH), a subtype of stroke, is associated with extremely high mortality and disability rates. The small-molecule compound B355252 exhibits neuroprotective effects against oxidative stress and ferroptosis. However, whether B355252 exerts protective effects against ICH-induced injury remains undefined. Furthermore, the therapeutic time window of B355252 for ICH has not been systematically elucidated. Therefore, this study aims to investigate the therapeutic effects of B355252 on ICH, elucidate its role and underlying mechanisms in inhibiting ICH progression, and determine its therapeutic time window. In this study, a mouse model of collagenase-induced intracerebral hemorrhage was established. Multifaceted assessments included histopathological analysis, behavioral te

SUBMITTER: Han B 

PROVIDER: S-EPMC12618391 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature