A Time and Motion Study Comparing Subcutaneous Pembrolizumab Versus Intravenous Pembrolizumab in Combination with Chemotherapy for the Treatment of Metastatic Non-small Cell Lung Cancer.

ABSTRACT:

Introduction

Subcutaneous (SC) formulations of oncology therapies could provide time-saving benefits for both patients and healthcare professionals (HCPs) compared with intravenous (IV) delivery. This prospective observational study, conducted alongside the MK-3475A-D77 phase 3, open-label randomized clinical trial, quantifies HCP and patient time with pembrolizumab SC versus pembrolizumab IV among patients with metastatic non-small cell lung cancer.

Methods

Seventeen sites across eight countries in Europe (n = 4), South America (n = 3), and Asia (n = 1) were enrolled. Primary endpoints were active HCP time; patient time in the treatment chair, treatment room, and healthcare facility; and consumables usage. Descriptive statistics included weighted mean (WM), and a linear mix

SUBMITTER: De Cock E 

PROVIDER: S-EPMC12618432 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature