Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging.

ABSTRACT: During aging, peripheral nerves undergo structural and cellular changes that trigger loss of function, impair quality of life, and increase disease risk. During peripheral nerve aging there are cellular and molecular changes, such as increased extracellular matrix deposition. The mechanisms behind these aging-induced alterations remain unclear. Here, we profile mouse sciatic nerves using single nucleus transcriptomics and unravel changes in macrophage subtypes during nerve aging. Phagocytic macrophage numbers increase at the onset of aging, followed by higher numbers of chronic inflammatory macrophages. Based on ligand-receptor analysis, we predict that increased fibroblast growth factor (FGF) signaling from adipocytes activates a chondrocyte-like neural fibroblast state during peripheral

SUBMITTER: Stefanovska D 

PROVIDER: S-EPMC12618493 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature