Effects of female hormone withdrawal and ulipristal acetate on MED12 mutation positive and negative uterine leiomyomas using a xenograft model.

ABSTRACT: The effects of therapeutic drugs that inhibit female hormone functions on uterine leiomyomas (ULMs) vary among individuals. ULMs are classified into two subtypes with different histological compositions: MED12 mutation-positive and -negative ULMs. The present study was undertaken to investigate the tumor regression effects of female hormone withdrawal and a selective progesterone (P) receptor modulator (ulipristal acetate, UPA) in the ULM subtypes using a xenograft mouse model. Smooth muscle cells (SMCs) isolated from each ULM subtype were transplanted and treated with estrogen (E) and P for 4 weeks to form the xenograft tumor. They were then divided into four groups: continued EP treatment (E(+)P(+)), EP withdrawal (E(-)P(-)), only P withdrawal (E(+)P(-)), and EP + UPA. Tumors were harves

SUBMITTER: Sato S 

PROVIDER: S-EPMC12618505 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature