Predicting tumor micronecrosis in hepatocellular carcinoma using pretreatment contrast-enhanced CT radiomics model: a multi-center study.

ABSTRACT: Tumor micronecrosis is a validated malignancy biomarker with poor prognosis in hepatocellular carcinoma (HCC), but currently lacks reliable preoperative detection methods. We developed a radiomics model for predicting tumor micronecrosis using preoperative contrast-enhanced computed tomography (CECT). The study included 1017 patients with histopathologically confirmed HCC across three centers, allocated to development, internal test, external test, and application sets. Radiomics features were extracted from tumor regions, with model training via a stratified 5-fold cross-validation framework. The model yield area under the curve values of 0.80 and 0.75 in the internal and external test sets, respectively. Survival curves for histologic and radiomics-predicted micronecrosis groups demonstr

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12618529 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature