Entamoeba muris provides a mouse model for amoebic colitis pathology characterized by T cell associated colonization.

ABSTRACT: Entamoeba (E.) histolytica is a major global health concern as the causative agent of amoebic colitis, yet research is hindered by the lack of an ideal animal model. While E. muris has been traditionally considered non-pathogenic, our study demonstrates that it induces a colitis-like pathology in BALB/c mice, making it a promising model for studying E. histolytica infection. Using a fecal-oral infection route, we confirmed successful E. muris colonization, leading to colonic inflammation characterized by early CD4 + T-cell infiltration and FOXP3 + regulatory T-cell recruitment. We further demonstrate that T-cell immunity is essential for E. muris colonization, as T-cell-depleted BALB/c mice and T-cell-deficient BALB/c nude mice failed to support persistent infection. Additionally, infectio

SUBMITTER: Ha TH 

PROVIDER: S-EPMC12618558 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature