Ben_0691 functions as an IRG-47 mycoplasma stimulator that mediates host cell resistance to Mycoplasma mycoides subsp. mycoides infection.

ABSTRACT: Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm), is a devastating cattle disease with high morbidity and mortality. Although mass vaccination or stamping-out strategy has controlled CBPP in many countries, it remains a major threat to cattle productivity in sub-Saharan Africa. An attenuated vaccine derived from serial passages of the virulent Ben-1 strain has eradicated CBPP in China, but the underlying immunoprotective mechanisms are unclear. While interferon-inducible GTPases are known to play a crucial role in host defense, IRG-47, an interferon-gamma (IFN-γ)-inducible GTPase, was previously thought to have limited anti-infective activity. Here, we demonstrate that IRG-47 is critical for defending against Mmm and is specifically upregulated

SUBMITTER: Liu T 

PROVIDER: S-EPMC12618582 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature