Evaluation of progesterone receptors with different cutoff values according to menopausal status in hormone-positive early breast cancer.

ABSTRACT: The impact of progesterone receptor (PR) expression level on breast cancer prognosis in relation to menopausal status is unclear. This study evaluated the impact of the association between PR expression level and menopausal status on prognosis in patients with estrogen receptor (ER)-positive (> 10%)/human epidermal growth factor receptor 2 (HER2)-negative breast cancer. We retrospectively identified 2,796 patients with ER-positive/HER2-negative early breast cancer and classified them into three groups based on PR expression levels: PR-high (> 10%), PR-low (1-10%), and PR-zero (< 1%). We compared the cumulative incidence of any recurrence (AR) and distant recurrence (DR) among the three groups by menopausal status. Over a median follow-up of 84.5 months, there were 324 AR and 264 DR events.

SUBMITTER: Ogawa A 

PROVIDER: S-EPMC12618652 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature