Effects of gestational diabetes mellitus on the intestinal microbiota of the offspring.

ABSTRACT: Gestational diabetes mellitus (GDM) significantly impacts maternal and neonatal health, yet its influence on the neonatal intestinal microbiota remains poorly characterized. This study investigated the effects of maternal GDM on offspring microbiota by analyzing meconium samples from newborns of GDM-affected mothers (n = 16) and healthy controls (n = 16). Microbiome analysis revealed distinct composition alterations in the intestinal microbiota of GDM-exposed neonates. Significant differences in microbial abundance were observed between groups: at the phylum level, the GDM group exhibited a significant increase in Bacteroidetes but significant reductions in Actinobacteria and Proteobacteria. At the genus level, opportunistic pathogens including Bacteroides and Escherichia-Shigella were sig

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12618659 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature