β-blockers and risk of neuropsychiatric adverse events: An active-comparator restricted disproportionality on the FAERS.

ABSTRACT:

Background

β-blockers (β-adrenoceptor antagonists), commonly used for cardiovascular conditions, may be linked to neuropsychiatric adverse events (AEs). However, many prevalent ones, including delirium and hallucinations, remain insufficiently studied.

Aims

To compare the neuropsychiatric risks of β-blockers with other antihypertensive drugs using data from the FDA Adverse Event Reporting System (FAERS) and differences between lipophilic and hydrophilic β-blockers.

Method

An active-comparator restricted disproportionality analysis was conducted using data from the FAERS (2004Q1-2023Q4). Neuropsychiatric AEs were analyzed using Preferred Terms and the System Organ Classes from the Medical Dictionary for Regulatory Activities for β-blockers compared to lisinopril and lo

SUBMITTER: Ez Eddin L 

PROVIDER: S-EPMC12618733 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature