The Signal Peptidase MoSpc2 Orchestrates Fungal Development, Protein Secretion and Pathogenicity in Magnaporthe oryzae.

ABSTRACT: The signal peptidase complex (SPC) is a crucial membrane enzyme complex involved in the process of protein secretion and maturation in both prokaryotic and eukaryotic cells. SPC is responsible for the cleavage of N-terminal signal sequences from nascent proteins, a sequence of amino acids that directs the newly synthesized protein to the secretory pathway. The yeast SPC is composed of four subunits: Spc1, Spc2, Spc3, and Sec11. To understand how SPC functions in the fungal plant pathogen, we identified the SPC component gene MoSPC2 and characterized its functions in M. oryzae. Through measuring the colony diameter of the ΔMospc2 mutant and control strains on culture medium plates, quantifying conidia production, observing conidial morphology, and assessing pathogenicity on rice and barley

SUBMITTER: Tang W 

PROVIDER: S-EPMC12618753 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature