LecB from Pseudomonas aeruginosa modulates Piezo1 currents and localization in a time-dependent manner.

ABSTRACT: Infections with the Gram-negative opportunistic pathogen Pseudomonas aeruginosa are becoming increasingly difficult to treat due to growing antibiotic resistance. Complications often include disturbed wound healing and impaired cell migration of various cell types, including epithelial and immune cells in the host tissue. One bacterial virulence factor responsible for these effects is the carbohydrate-binding lectin LecB. It mediates adhesion to host cells, alters various cellular signaling pathways and internalizes several receptors, i.e. integrins. However, the full effects and mechanisms of how LecB influences the processes in the host cells are still largely unknown. In this study, we introduce a new host cell interaction partner of LecB with strong physiological impact. Using immunofl

SUBMITTER: Kittel AS 

PROVIDER: S-EPMC12618757 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature