Fibroblast-derived interleukin-11 as a potential biomarker for intestinal fibrostenosis in Crohn's disease.

ABSTRACT:

Background

Intestinal fibrosis-associated stricture can lead to bowel complications and subsequent surgeries in patients with Crohn's disease (CD), but there are no widely accepted biomarkers for intestinal fibrostenosis.

Objectives

This study aims to investigate the value of interleukins (IL) in detecting CD-related intestinal fibrostenosis.

Design

This is an observational study.

Methods

Transcriptomic profiling was performed from paired CD surgical resections containing non-involved and fibrostenotic segments. Data were integrated with a public dataset and a Luminex-based serum assay to identify fibrosis-related interleukins, which were further validated at mRNA and protein levels. Correlations with clinical indicators and surgical outcome were analyzed. Last

SUBMITTER: Tan J 

PROVIDER: S-EPMC12618813 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature