Antibiotic impact on human microecology in low- and middle-income countries: a systematic age-stratified review of gut and respiratory microbiome and resistome.

ABSTRACT:

Background

Antibiotic exposure disrupts microbial communities in the gut and respiratory tract, causing functional changes that may have lasting health impacts and contribute to the spread of antibiotic resistance genes (ARGs) throughout life. However, age-stratified evidence of these effects, particularly in low- and middle-income countries (LMICs), remains limited.

Objective

This systematic review assessed the impact of antibiotics on gut and respiratory microbiomes and resistomes in LMICs, with separate analyses for adults and children.

Data sources

PubMed, Scopus, Web of Science, & ScienceDirect.

Methods

A comprehensive literature search was conducted using a predefined search strategy and eligibility criteria to identify relevant studies from LMICs. Twenty

SUBMITTER: Yartey SN 

PROVIDER: S-EPMC12618827 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature