Tumor cell- and infiltrating immune cell-based supervised learning artificial intelligence multimodal platform for tumor prognosis.

ABSTRACT: Survival assessment for oral squamous cell carcinoma (OSCC) remains a significant clinical challenge. This study develops novel artificial intelligence (AI) platforms for assessing overall survival in OSCC patients based on 240 whole-slide images from multicenter cohorts. A comprehensive evaluation is conducted on four convolutional neural network architectures under two distinct deep learning (DL) training paradigms: supervised DL with precise annotations (PathS model, c-index = 0.809), and weakly supervised DL using slide-level labels without manual annotations (c-index = 0.707). Gradient-weighted class activation mapping reveals novel AI-based prognostic insights to simultaneously identify tumor cells and tumor-infiltrating immune cells as key predictive features. Additionally, our plat

SUBMITTER: Cai XJ 

PROVIDER: S-EPMC12618876 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature