Epoxy tetrahydrophthalimides as potential bioactive agents: synthesis and computational study.

ABSTRACT:

Background

Due to the growing resistance of weeds to known herbicides, the search for new bioactive substances has been increasing in recent years. Imides belong to an important class of chemical compounds known to present various biological activities such as herbicide, fungicide, insecticide, and bactericide. In this study, the synthesis, purification, structural elucidation, and bioassays of four pairs of epoxy tetrahydrophthalimides 15a-18a and 15b-18b were conducted. Additionally in silico studies were performed to identify potential biological targets for the synthesized compounds.

Results

The target compounds were prepared using a four-step synthetic route that starts with a microwave-assisted Diels-Alder reaction between maleic anhydride and isoprene. All synthesized

SUBMITTER: Amorim Torrent KB 

PROVIDER: S-EPMC12618921 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature