Human Sputum Microbiome Composition and Sputum Inflammatory Cell Profiles Are Altered with Controlled Wood Smoke Exposure as a Model for Wildfire Smoke.

ABSTRACT: Rationale: Wood smoke exposure is increasing worldwide because of the increase in wildfire events. Various studies have associated exposure to wildfire-derived smoke with adverse respiratory conditions. However, the mechanism by which this occurs is unknown. Previous studies using wood smoke as a model of wildfire smoke have focused on the respiratory immune response and have reported increased neutrophil percentage and cytokine production in airway samples. The effect of wood smoke on the respiratory microbiome, however, has not been examined. Objectives: The objective of this study was to evaluate whether inhaled wood smoke exposure can alter the respiratory microbiome in humans. Methods: Healthy volunteers (N = 54) were subjected to controlled wood smoke expo

SUBMITTER: Cobos-Uribe C 

PROVIDER: S-EPMC12619000 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature