Interventions for Bowen's disease: A systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT: Bowen's disease (BD) is an intraepidermal malignancy that may progress to skin cancer, yet no study has compared interventions from randomized controlled trials (RCT). We synthesized RCT data to calculate lesion-specific initial clearance rates, long-term clearance rates, and cosmetic outcomes relative to placebo. We searched MEDLINE, EMBASE, CENTRAL and trial registers up to September 30, 2024, and included nine studies (672 patients, 844 lesions). Interventions compared to placebo and ranked via network meta-analysis included surgery, imiquimod, photodynamic therapy (PDT), laser ablation (LA), laser-assisted PDT (LA-PDT), cryotherapy and 5-fluoruracil (5-FU). Bias was assessed using the revised Cochrane risk-of-bias tool. The study was registered in PROSPERO prior to data extraction (CRD

SUBMITTER: Foerster Y 

PROVIDER: S-EPMC12619046 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature