Complex sphingolipid metabolism impacts cell division and plasmodesmal development in the moss Physcomitrium patens.

ABSTRACT: Developmental patterning and organ structure are elegantly simple in the moss Physcomitrium patens, which facilitates the cultivation and phenotypic characterization of severe mutant alleles. Essential membrane lipids, such as complex phosphosphingolipids (in plants, glycosyl inositol phosphorylceramides, GIPCs), are difficult to functionally characterize due to non-viable and pleiotropic phenotypes of mutants affected in their synthesis. Following the isolation and biochemical characterization of mutants affected in GIPC synthesis in P. patens, including sphinganine-C4-hydroxylase/sphingoid base hydroxylase (s4h/sbh) and inositol phosphorylceramide synthase (ipcs), we report some of their morphological, histological, and cytological phenotypes. We observed alterations in cell division, ex

SUBMITTER: Wegner L 

PROVIDER: S-EPMC12619088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature