Transepidermal Water Loss in Oral Food Challenges in Children With Peanut Allergy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Food allergy is a prevalent chronic medical condition in children, with limited diagnostic options. Transepidermal water loss (TEWL) is a measure of skin barrier function with emerging utility in atopy and food allergy.

Objective

To determine whether use of TEWL as a stopping criterion can prevent anaphylaxis during a peanut oral food challenge (OFC).

Design, setting, and participants

This was a single-center randomized clinical trial of children aged 6 months to 5 years with a history of a clinical peanut allergic reaction and positive peanut skin prick and/or serum immunoglobulin E testing. All participants underwent peanut OFC at an allergy referral clinic. The study began May 1, 2023, and ended August 31, 2024.

Intervention

The intervention was s

SUBMITTER: Freigeh GE 

PROVIDER: S-EPMC12619095 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature