Rotenone targets midbrain astrocytes to produce glial dysfunction-mediated dopaminergic neurodegeneration.

ABSTRACT: Exposure to pesticides, such as rotenone or paraquat, is an environmental factor that plays an important role in the pathogenesis of Parkinson's disease (PD). Rotenone induces PD-like pathology and is therefore used to develop parkinsonian animal models. Dopaminergic neurotoxicity caused by rotenone has been attributed to the inhibition of mitochondrial complex I, oxidative stress and neuroinflammation; however, the mechanisms underlying selective dopaminergic neurodegeneration by rotenone remain unclear. To resolve this, we focused on glial diversity and examined whether the brain region-specific glial response to rotenone could determine the vulnerability of dopaminergic neurons using primary cultured neurons, astrocytes and microglia from the midbrain and striatum of rat embryos and rot

SUBMITTER: Miyazaki I 

PROVIDER: S-EPMC12619187 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature