B-cell maturation antigen targeted PET/CT imaging in multiple myeloma: a first-in-human study.

ABSTRACT: B-cell maturation antigen (BCMA)-targeted positron emission tomography/computed tomography (PET/CT) represents a promising tool for the management of multiple myeloma, enabling noninvasive and quantitative evaluation across different disease stages. This novel technique specifically addresses two major diagnostic challenges: the limited specificity of conventional ¹⁸F-FDG PET/CT and the focal sampling constraints of bone marrow biopsies. In this prospective study, a ⁶⁸Ga-labeled nanobody-based BCMA tracer demonstrated improved detection compared with ¹⁸F-FDG PET/CT, effectively visualizing para-medullary, extra-medullary and medullary lesions, as well as minimal residual disease (MRD). The tracer also reflected dynamic changes in BCMA expression associated

SUBMITTER: Gu T 

PROVIDER: S-EPMC12619229 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature