Hormonal and reproductive factors and risk of nasopharyngeal carcinoma in Chinese women: a case-control study.

ABSTRACT:

Background

Sex hormones may play a role in the development of nasopharyngeal carcinoma (NPC), but the evidence is limited.

Methods

This case-control study collected information on sex hormonal and reproductive factors of 99 female incident NPC cases and 109 female controls in Hong Kong through face-to-face interviews.

Results

An increased risk of NPC associated with late menarche and spontaneous miscarriage history was indicated when adjusted for age only, the age-adjusted odds ratio (OR) were 2.22, 95% confidence interval (CI) 1.04-4.72 for menarche at ages > 14 years, 2.31 (95% CI 1.03-5.18) for one miscarriage, and 4.00 (95% CI 1.04-15.31) for ≥ 2 miscarriages. But such associations were attenuated after adjustment for additional potential confounders, the fully-ad

SUBMITTER: Su XY 

PROVIDER: S-EPMC12619248 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature