Molecular mechanisms by which C1orf112 promotes endometrial cancer progression and the development and validation of a clinical scoring model.

ABSTRACT:

Objective

To investigate the expression profile, clinical significance, and underlying molecular mechanisms of C1orf112 in endometrial cancer (EC).

Methods

We performed bioinformatics analyses using data from The Cancer Genome Atlas to evaluate C1orf112 expression and its association with clinicopathological parameters in EC. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, as well as protein-protein interaction network analysis, were conducted to explore the functional roles and regulatory pathways of C1orf112. A multi-omics integrative approach was used to elucidate the regulatory mechanisms underlying C1orf112 expression. Furthermore, we constructed and validated a prognostic scoring model incorporating C1orf112 expression.

Results

C1o

SUBMITTER: Wang L 

PROVIDER: S-EPMC12619259 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature