Exploratory development of biomarkers for neurobehavioral performance impairment during sleep loss: comparison across multiple types of sleep deprivation.

ABSTRACT:

Background

Inter-individual variation in response to insufficient or altered timing of sleep presents a challenge for the development of personalized approaches to fatigue monitoring and mitigation. Insufficient sleep has adverse health impacts, can result in impaired neurobehavioral performance, and can substantially increase the risk of injury and even mortality in safety-critical operations such as transportation. The present study provides a detailed exploration of physiological, neurobehavioral, and gene expression changes during sleep restriction, acute total sleep deprivation, and altered timing of sleep among 59 healthy volunteer participants who completed a 10-day inpatient study.

Results

Reducing the quantity or altering the timing of sleep significantly impacts se

SUBMITTER: Uyhelji HA 

PROVIDER: S-EPMC12619276 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature