Real-world analysis and future trends of parkinson's disease burden and all-cause mortality in Shanghai Pudong: a population-based study of 3.17 million people.

ABSTRACT:

Background

To assess all-cause Parkinson's disease (PD)-related and PD-specific mortality trends and years of life lost (YLL) in Shanghai Pudong (3.17 million population) from 2005-2021, and project future burdens through 2035.

Methods

Using population-level mortality data including 4,218 PD-related deaths among 362,558 total deaths, we calculated crude mortality rates (CMR), age-standardized mortality rates (ASMRW), and YLL. Temporal trends were analyzed by the average annual percent change (AAPC) via Joinpoint regression, demographic impacts via decomposition methods, and future projections via ARIMA models.

Results

PD-related CMR and ASMRW were 8.74/100,000 and 2.76/100,000, respectively, with 31,904.41 YLL. PD-specific mortality rates (CMR: 3.76/100,000; ASMRW: 1.

SUBMITTER: Luo Z 

PROVIDER: S-EPMC12619288 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature