Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation.

ABSTRACT:

Background

Depression, a prevalent mental disorder worldwide, is associated with pathological mechanisms including neuroinflammation. Pediococcus acidilactici has shown the potential neuroprotective effects, yet its role in ameliorating depression and the underlying mechanisms remain unclear.

Methods

Eight-week-old male C57BL/6J mice were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks to establish a depression model. Mice were orally administered Pediococcus acidilactici CGMCC 35671 (strain GOLDGUT-EZMind) (1 × 10⁹ CFU/day). Behavioral experiments and biochemical assays were conducted to evaluate its effects on CUMS-induced anxiety and depressive-like behaviors. Serum indole-3-lactic acid (ILA) concentrations and aryl hydrocarbon receptor (AHR)

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12619292 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature